Surrogate outcomes and transportability
نویسندگان
چکیده
منابع مشابه
Surrogate outcomes: a cautionary note.
See related article, pages 1353–1358. Drug development for acute stroke treatments is complex, very expensive, very time-consuming, and frequently disappointing. Surrogate outcome theory states that new therapies for stroke could be evaluated with smaller sample sizes than are required when traditional functional outcome measures are used by using surrogate outcomes in clinical trials. This wou...
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A surrogate outcome can be defined as an outcome that can be observed sooner, at lower cost, or less invasively than the true outcome, and that enables valid inferences about the effect of intervention on the true outcome. There is increasing interest in the use of surrogate outcomes of treatment efficacy measurement in investigational drug trials. However, the significance of surrogate markers...
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Surrogate outcomes are frequently used in cardiovascular disease research. A concern is that changes in surrogate markers may not reflect changes in disease outcomes. Two recent clinical trials (Heart and Estrogen/Progestin Replacement Study [HERS], and the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial [ALLHAT]) underscore this problem since their results contradic...
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ژورنال
عنوان ژورنال: International Journal of Approximate Reasoning
سال: 2019
ISSN: 0888-613X
DOI: 10.1016/j.ijar.2019.02.007